| Nicotine identity and assay | Clearly defined material identity, concentration, units, and test method, with results tied to the supplied batch. | Batch-specific certificate of analysis (COA); analytical method summary; representative chromatograms or test data where appropriate. | Check that the batch number, product description, concentration, and units match across the COA, label, and purchase documents. Independently test a sample when risk warrants it. | Critical |
| Impurities and composition | A documented specification for relevant impurities and formulation components, with acceptance limits and a defined testing plan. | Product specification; impurity profile; test methods; change-control records for formulation or process changes. | Review whether the listed tests and limits suit the intended use and destination requirements; do not treat a generic COA as proof of every safety attribute. | Critical |
| Independent laboratory capability | Access to qualified testing, with the scope of any laboratory accreditation relevant to the specific test being relied upon. | Laboratory report; accreditation certificate and scope, if claimed; sample identification and chain-of-custody details. | Verify accreditation directly with the issuing body and confirm that the relevant analytical method is within scope. Accreditation alone does not guarantee product compliance. | High |
| Batch traceability | Traceability from incoming materials through production, testing, packaging, and dispatch, using consistent lot identifiers. | Batch records; lot-coding procedure; supplier and raw-material traceability records; recall procedure. | Ask the supplier to demonstrate how one finished lot can be traced back to its materials and forward to its customers or shipments. | High |
| Manufacturing controls | Written procedures for production, equipment cleaning, contamination prevention, deviations, and corrective actions. | Quality manual or relevant procedures; audit summary; training and calibration records; corrective and preventive action (CAPA) examples. | Assess whether controls match the product and the buyer’s intended use. Treat management-system certificates as supporting evidence, not a substitute for product-specific checks. | High |
| Safety data and hazard communication | Current safety documentation that accurately reflects the supplied material and is prepared for the relevant market and language. | Safety data sheet (SDS); hazard classification rationale; label artwork or specimen; emergency and handling information. | Check consistency between the SDS, product concentration, packaging, and transport documents. Confirm local format and language requirements for the destination. | Critical |
| Regulatory and market access | A clear explanation of which product category and markets the supplier supports, without implying that one approval covers every jurisdiction. | Applicable registrations, permits, declarations, or conformity documents; product-specific regulatory dossier where relevant. | Confirm current requirements with the destination-market authority or a qualified adviser. Verify document validity, scope, holder, and product coverage directly. | Critical |
| Packaging and labeling | Packaging suitable for the material and shipment, with accurate identification and any locally required safety features or warnings. | Packaging specification; label proof; closure and compatibility information; packaging test records where applicable. | Review the final market-specific label and packaging before production. Child-resistant or other special packaging requirements depend on the jurisdiction and product category. | High |
| Transport and export documentation | Shipment classification and documentation determined by the actual product, concentration, packaging, route, and applicable transport rules. | Transport classification assessment; shipping declaration where required; commercial invoice; packing list; export documents. | Have the carrier or dangerous-goods specialist confirm applicable requirements for the specific shipment. Do not assume all nicotine liquids have the same transport classification. | High |
| Change control and complaint handling | Advance notification of material, process, site, specification, or packaging changes, plus a documented process for investigating complaints. | Change-control procedure; complaint and deviation records; escalation contacts; recall and notification workflow. | Agree in writing which changes require buyer approval and how affected lots will be identified, investigated, and handled. | Medium–High |
| Commercial consistency | Quotes and contracts that define grade, specification, test requirements, batch documentation, packaging, delivery terms, and remedies for nonconformance. | Written quotation; product specification attached to contract; sample and inspection terms; agreed incoterm and delivery schedule. | Ensure the purchase order references the approved specification and requires batch-specific documents before shipment. | Medium–High |